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Daharwal, S. J.
- Development of Classical Least Square Method for the Determination of Candesartan and Hydrochlorthiazide in Tablet Dosage Form
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 2 (2015), Pagination: 90-95Abstract
A new simple spectrophotometric method was developed for the determination of binary mixtures of Candesartan cilexetil (CAND) and Hydrochalorothiazide (HCTZ), without prior separation. The method is based on the multi-wavelength technique i.e. classical least square (CLS) method. The tablet is determined by the multi-wavelength technique (CLS), at the wavelengths range of 215-225 nm over the concentration ranges of 2.5-50 and 1-30 μg/mL with mean recovery more than 98% for both drugs CAND and HCTZ, respectively. The proposed spectrophotometric method was validated and successfully applied for the assay of drug combination in several laboratory-prepared mixtures and commercial tablets.Keywords
Spectrophotometric Analysis, Classical Least Square Method, Candesartan, Hydrochlorothiazide.- Designing and Optimization of Medicated Chewing Gum of Ambroxol HCl by Using 32 Factorial Design
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
Source
Asian Journal of Pharmaceutical Research, Vol 3, No 3 (2013), Pagination: 118-120Abstract
The present work deals with optimization of designed MCG , so that the best possible set of parameters affecting result can be selected to get the desired output. In this report nine batches of formulations (F1-F9) prepared and studied. Two variables were selected for the formulations in which first was concentration of elastomer and other was concentration of softener. The mathematical models developed for all the dependent variables using statistical analysis software Design experts 8.0.1.Percent Drug release of various formulation F2, F5, F8 andF9 was found to be 95.31, 98.74, 88.18 and 91.74. The highest Percent of Drug release among all is of F5.Keywords
Optimization, Medicated Chewing Gum, Ambroxol HCl.- Designing and Optimization of Modified Dissolution Apparatus for Evaluation of Medicated Chewing Gum of Ambroxol HCl
Abstract Views :188 |
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN